Luba Orgonasova's home town of Bratislava has long been one of the major regional musical centers of Central Europe. She attended the Conservatory and the Music Academy of the city, where she studied piano and voice.
She began her singing career at Bratislava's opera house, then was invited to sing as a guest at the Hagen Opera House in 1984. Following that appearance, she received a contract as a member of that company as its First Lyric Soprano, remaining there to the end of the 1988 season. While there she sang in many leading parts, including two for which she would become famous, Violetta in Verdi's La Traviata and Pamina in Mozart's Die Zauberflöte. She sang Pamina at the Vienna State Opera and recorded it in 1989.
Maestro Herbert von Karajan heard her sing and invited her to appear in the 1990 Salzburg Easter Festival and the summer Salzburg Festival in 1990, where she sang Marzelline in Beethoven's Fidelio. Later in that season she sang Donna Anna in Mozart's Don Giovanni at the Vienna State Opera and Konstanze in Die Entführung aus dem Seraglio in Paris.
Since then she has sung on all the major operatic stages of the world, and in concert performance with many of the great orchestras. Among her signature roles is that of Eurydice in Gluck's Orphée et Eurydice.